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Physicians

Why Genomic Testing?

Pharmacogenetics is the study of drug interaction with an individual's genetic makeup and can provide a vital piece of information to aid the physician when selecting a patient's medication and initial dosage.  This circumvents the trial and error approach and helps eliminate adverse drug reactions or lack of therapeutic effect under standard therapy conditions.

 

The report from our genetic panels are easy to read and will outline the metabolizer status specific to your patient.  This will allow more personalized medicine selection and dosage, based on a case-by-case ability to metabolize a drug.

 

Learn more about each panel

We offer a series of genetic panels that show you how well your body metabolizes certain medicines.

The pain panel assesses which pain medications and dosages are appropriate for the patient in question. Surprisingly, the percentage of patients who react to their medications as intended ranges only between 25-60%.  Another surprising statistic is that about 106,000 Americans die annually from Adverse Drug Reactions.  By testing the patient's reaction to drugs metabolized by the CYP450 enzymes, we can determine the appropriateness and dosage of most of the commonly prescribed drugs, including:

 

  • Codeine
  • Oxycodone
  • Fentanyl
  • Methadone
  • Beta Blockers

This panel helps to prevent adverse reactions caused by taking heart and blood medications.  By reducing the amount of people that take medicine that they are naturally not capable of processing at a normal rate, we can reduce the variability in the pharmacodynamic response to these medicines.  Patients with a reduced ability to metabolize certain drugs are at a greater risk for adverse cardiovascular events.  For example, 25% of patients taking the drug clopidogrel (Plavix) experience a sub-therapeutic antiplatelet response that is associated with an increased risk of recurrent ischemic events.  The Cardio Panel* provides genetic results for:

  • CYP2C19
  • CYP2D6
  • VKORC1 and 2C9
  • Factor V Leiden
  • Factor 2
  • MTHFR

INTERMEDIATE METABOLIZER

Effects of DNA on drug effacacy

ULTRA-RAPID METABOLIZER

SLOW (POOR) METABOLIZER

Normal metabolizers, also referred to as "Rapid metabolizers" metabolize medications normally  and typically are prescribed according to guidelines intended by the drug's manufacturer and attending physician

Drugs can be broken down too quickly or improperly, requiring a higher dosage or change in medication in many cases.

Drugs are not metabolized fast enough resulting in either too little or too much of the drug in the body.

Drugs, supplements and some foods will reduce or increase the effectiveness of the medication.